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Schematic Representation of the Experimental Procedures Employed to Evaluate the Inhibition of NC Binding to TAR by Selected Ligandsa
aThe red oval represents the ligand. (i) Displacement of NC●TAR complex was analyzed by adding ligand to the preformed protein-RNA complex; (ii) interaction of NC with TAR substrate was assayed after preincubation of the protein with ligand; (iii) NC protein was added to preformed TAR-ligand complexes.
