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Inhibition of NC-Mediated Melting of Individual TAR and cTAR Structures
| Compound | IC50 TARa (μM) | IC50 cTARa (μM) |
|---|---|---|
| D-4a | 39.7 ± 3.99 | 24.9 ± 2.20 |
| D-4b | 8.79 ± 0.11 | 12.8 ± 1.09 |
| D-4c | 51.3 ± 5.01 | 32.1 ± 2.76 |
| D-4d | 33.7 ± 2.05 | 19.9 ± 1.58 |
| D-4e | 10.5 ± 1.50 | 13.8 ± 1.50 |
| D-4f | 9.24 ± 0.49 | 6.52 ± 0.47 |
| D-4g | 3.27 ± 0.44 | 4.76 ± 0.68 |
| D-4h | 3.35 ± 0.51 | 2.16 ± 0.37 |
| D-4i | 47.4 ± 1.34 | 20.2 ± 0.78 |
Values are the mean of data obtained from three experiments, each performed in triplicate
