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Distinct and overlapping characteristics of Tcm, Tem, and Trm cells
| Can cross HEV | Can be sampled in blood | Migrate to inflamed NLT | Recirculate through uninflamed NLT | Dominant surveyor of NLT | |
|---|---|---|---|---|---|
| Tcm | Yes | Yes | Yes | Limited evidence, but likely rare | No |
| Tem | No | Yes | Yes | Yes (some subsets) | No |
| Trm | No | No | No | No | Yes |
Abbreviations: HEV, high endothelial venule; NLT, nonlymphoid tissue; Tcm, central memory T; Tem, effector memory T; Trm, resident memory T.
