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. Author manuscript; available in PMC: 2020 Apr 22.
Published in final edited form as: Sci Signal. 2019 Jan 1;12(562):eaar6889. doi: 10.1126/scisignal.aar6889

Figure 2. Dendritic AMPAR trafficking.

Figure 2.

AMPARs are synthesized either in the soma (not depicted) or dendritic shaft in the endoplasmic reticulum (ER). From the dendritic ER AMPARs traffic through the ER–Golgi intermediate compartment to recycling endosomes, which mediate surface insertion of AMPARs (31). It is unclear where exactly exocytosis occurs but it is likely either in the dendritic shaft near dendritic spines or in dendritic spines outside the postsynaptic density (PSD). AMPARs then move through lateral diffusion to the PSD, where they are trapped by PSD-95 and its homologues through their binding to the C-termini of TARPs. PSD-95 is anchored at postsynaptic sites by α-actinin. When and where TARPs, which are mostly if not exclusively translated in the soma (31), associate with AMPARs and especially those synthesized in dendrites is unknown. Credit: Kellie Holoski/Science Signaling