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. Author manuscript; available in PMC: 2020 Apr 22.
Published in final edited form as: Sci Signal. 2019 Jan 1;12(562):eaar6889. doi: 10.1126/scisignal.aar6889

Figure 5. Regulation of postsynaptic AMPAR trafficking.

Figure 5.

LTP-inducing stimuli trigger the influx of Ca2+ through NMDARs. Ca2+ binds to CaM and stimulates the activity of CaMKII. CaMKII is then recruited to the NMDAR complex by binding to the C-terminus of the GluN2B subunit. It subsequently phosphorylates the C-termini of TARPs including γ2 and γ8, which may lead to AMPAR trapping at the PSD. Phosphorylation of GluA1 on Ser831 by CaMKII also augments its channel activity. Credit: Kellie Holoski/Science Signaling