Hesse 2005.

Methods	Randomised clinical trial (parallel design)
Participants	Country: Belgium Sample size: 105 Post‐randomisation drop‐out: 0 Revised sample size: 105 Females: 27 (25.7%) Mean age: 59.5 years Malignancy: 71 (67.6%) Chronic pancreatitis: 26 (24.8%) Pancreatoduodenectomy: 80 (76.2%) Follow‐up: not reported Inclusion criteria: 1. Aged 16‐86 years 2. Pancreaticojejunostomy
Interventions	The participants were randomly assigned to 2 groups Group 1: octreotide (n = 56) Further details: at the time of operation in a dose of 0.1 mg sc 3 times a day for 7 days Group 2: control (n = 49) Further details: no intervention
Outcomes	The outcomes reported were mortality, perioperative morbidity and hospital stay
Notes	Pancreatic fistula definition: drainage of more than 100 mL/day of amylase rich fluid which had to be more than 5 times the upper limit of normal serum amylase after day 3 and persisting after postoperative day 7 with raising temperature and pre‐septic conditions (grade B)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "was performed according to a computer generated random list"
Allocation concealment (selection bias)	Unclear risk	Comment: this information was not available
Blinding (performance bias and detection bias) All outcomes	High risk	Quote: "single center open label prospectively randomized trial"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: "There were no post‐randomisation drop‐outs"
Selective reporting (reporting bias)	High risk	Comment: important outcomes like re‐operation and adverse effects of octreotide were not reported
Free of source of funding bias?	Unclear risk	Comment: this information was not available