Beguiristain 1995.

Methods	Randomised clinical trial (parallel design)
Participants	Country: Spain Sample size: 35 Post‐randomisation drop‐out: not stated Revised sample size: 35 Females: 10 (28.6%) Mean age: 59.4 years Malignancy: 30 (85.7%) Chronic pancreatitis: 3 (8.6%) Pancreatoduodenectomy: 35 (100%) Follow‐up: not reported Inclusion criteria: 1. Pancreaticoduodenectomy
Interventions	The participants were randomly assigned to 2 groups Group 1: somatostatin (n = 21) Further details: continuous infusion 4.5 mg/day starting immediately after surgery for 7 days Group 2: control (n = 14)
Outcomes	The outcomes reported were mortality and perioperative morbidity
Notes	Pancreatic fistula definition: drainage of at least 10 mL of fluid with an amylase concentration of more than 5 Somogyi units (grade A)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: this information was not available
Allocation concealment (selection bias)	Unclear risk	Comment: this information was not available
Blinding (performance bias and detection bias) All outcomes	High risk	Comment: blinding was probably not performed
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Comment: this information was not available
Selective reporting (reporting bias)	High risk	Comment: some important outcomes were not reported
Free of source of funding bias?	Unclear risk	Comment: this information was not available