Terms	Definition	Source
Hb SS	An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.	Nattional Library of Medicine; Mesh home page.
Hb SC	One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.	Nattional Library of Medicine; Mesh home page.
L‐carnitine	A derivative of the amino acid lysine , required for the transport of fatty acids into mitochondria for oxidation.	Bender 2009
Solcoseryl®      DuoDerm	Solcoseryl® is a tissue metabolism activator, chemically and biologically standardized and deproteinised, non antigenic and apyrogenic hemodialized extract form the blood of healthy young calf. Solcoseryl® contains a large amount of natural low molecular substances ‐ glycolipides, nucleosides, nucleotides, amino acids, oligopeptides, irreplaceable micro elements, electrolytes.   Duoderm (Granuflex®, Convatec, Uxbridge, UK, marketed as DuoDerm® in the USA) A hydrocolloid dressing containing colloids and elastomeric and adhesive components.	http://www.drugspro.org/     O'Meara 2000
RGD peptide matrix	Arginine‐glycine‐aspartic acid (RGD). RGD peptide matrix is designed to act as a temporary, topical synthetic extracellular matrix that substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site. This synthetic matrix consists of an RGD‐containing peptide complexed with sodium hyaluronate in a sterile, non preserved viscous gel. Arginine‐glycine–aspartic acid (RGD) peptide matrix (Argidene Gel®, formerly Telio‐Derm Gel®, Telios Pharmaceuticals, San Diego, CA, USA) The peptide matrix contains the arginine‐glycine‐aspartic acid amino acid sequence, by which cells in vivo become attached to extracellular matrix macromolecules via surface integrin receptors. The matrix is a sterile non‐preserved clear viscous gel, formulated in phosphate‐buffered saline and dispensed from a single‐use syringe container. The functional ingredient of RGD peptide matrix is a complex formed by the combination of a synthetic 18 amino acid peptide and sodium hyaluronate. It also contains added unconjugated sodium hyaluronate as a viscosity‐increasing agent, and therefore does not require preparation from patient samples.	Wethers 1994 O'Meara 2000
Isoxsuprine	ß‐Adrenergic receptor stimulants drug.	http://dailymed.nlm.nih.gov
Oral zinc sulphate	A salt of zinc used as a supplement for treating zinc deficiency	Bender 2009
Arginine butyrate	The butyric acid salt of the amino acid arginine.	http://www.cancer.gov/drugdictionary
Haemoglobinopathy	Any of a group of inherited diseases, such as thalassaemia and sickle‐cell disease , in which there is an abnormality in the production of haemoglobin.	Martin 2011
Priapism	Persistent and usually painful erection of the penis that requires urgent decompression; occasionally, however, it can be painless, in which case its treatment is less urgent.	Martin 2011
Pulmonary hypertension	Condition in which there is raised blood pressure within the blood vessels supplying the lungs (the pulmonary artery blood pressure is normally much lower than the pressure within the aorta and its branches).	Martin 2011
Nitric oxide	An important member of the group of gaseous mediators, which – together with amine mediators (e.g. adrenaline, noradrenaline, histamine, acetylcholine) and lipid mediators (e.g. prostaglandins) – produce many physiological responses	Martin 2011
Endothelium	The single layer of cells that lines the heart, blood vessels, and lymphatic vessels.	Martin 2011
Antithrombin III	Coagulation inhibitory protein	Santen 2004