Trials	Assessment of ulcer healing	Change in ulcer size (surface area or volume)	Complete closure
Baum 1987	"Ulcer was measured in two dimensions and photographs taken for determination of ulcer" as described by Serjeant 1970.	‐	‐
La Grenade 1993	It was analysed from the measured long and short dimensions of the ulcer, arbitrarily assuming and elliptical shape.	It was expressed as in real changes and percentage changes in area.	‐
McMahon 2010	"During the weekly clinical visits, the ulcer was traced on acetate film and photographed. All ulcer areas were then calculated by computerized planimetry, using the IMAGEJ software (NIH, Bethesda, MD, USA)".	NA	Complete closure of the ulcer (to an area of 0 cm2).
Serjeant 1977	"The ulcer periphery was defined on the photograph, cut out, weighed, and the area of the ulcer calculated from the weight/area ratio of the photographic paper".	Default: "defined as less than 4 months satisfactorily attendance at the trial". No change: "variation of less than 1 cm2 in ulcer area during the 6‐month period". Healed ulcers "expressed as a proportion of those ulcers likely to heal on the basis of small size (8 cm2).	‐
Serjeant 1997	"Ulcer size was measured by area (measured in square centimeters), computing an assumed ellipse from long and short axis measurements. When more than one ulcer was present, the average area calculated for that patient was used in the analysis".	Period: 12 weeks. "(1) absolute change in area (change in ulcer area over treatment period divided by number of weeks on treatment) x 12 and (2) percentage change in area (absolute change in area + area at start of treatment)".	‐
Wethers 1994	"Changes in percent ulcer closure occurring between study commencement and endpoint".	‐	‐