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. 2020 Apr 15;10:424. doi: 10.3389/fonc.2020.00424

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Copyright © 2020 Bi, Wei, Qin and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmaps, Venn plots, and enrichment analysis of GO and KEGG for DEGs. (A) Heatmap for DEGs generated by comparison of the high score group vs. the low score group in ImmuneScore. Row name of heatmap is the gene name, and column name is the ID of samples which not shown in plot. Differentially expressed genes were determined by Wilcoxon rank sum test with q = 0.05 and fold-change >1 after log₂ transformation as the significance threshold. (B) Heatmap for DEGs in StromalScore, similar with (A). (C,D) Venn plots showing common up-regulated and down-regulated DEGs shared by ImmuneScore and StromalScore, and q < 0.05 and fold-change >1 after log₂ transformation as the DEGs significance filtering threshold. (E,F) GO and KEGG enrichment analysis for 379 DEGs, terms with p and q < 0.05 were believed to be enriched significantly.