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Summary of S1PR signaling pathway-mediated regulation of cell survival through piR-004800 in multiple myeloma cells. S1P binds to and activates S1P receptors (S1P1~S1P5) which all can couple to Gi/o, and CDC42 is the downstream of Gi/o. S1PR signaling pathway regulates PI3K/Akt/mTOR pathway through piR-004800 to affect apoptosis and autophagy in MM cells, by which to keep cell survival. FTY720 acts as a S1PRs' inhibitor.
