Table 1.
Characteristics of the total study sample and according to cSVD score
| Variable | Total | cSVD 0 | cSVD 1 | cSVD 2 | cSVD 3/4 | *p-value |
| n | 82 | 18 | 20 | 21 | 23 | |
| Age (y) | 71.2±7.9 | 64.7±7.8 | 68.9±5.5 | 73.6±5.6 | 76.2±7.6 | <0.001 |
| Sex (% female) | 28 (34.1) | 5 (27.8) | 7 (35.0) | 9 (42.9) | 7 (30.4) | 0.758 |
| Living with spouse (%) | 60 (73.2) | 14 (77.8) | 18 (90.0) | 12 (57.1) | 16 (69.6) | 0.113 |
| Education (y) | 11.0±2.8 | 10.9±2.8 | 11.7±2.8 | 11.6±3.4 | 11.3±2.9 | 0.771 |
| BMI (kg/m2)** | 25.7±4.1 | 27.3±5.4 | 27.1±4.2 | 23.8±3.2 | 24.9±3.0 | 0.031 |
| History of CVD (%) | 24 (29.3) | 8 (44.4) | 7 (35.0) | 5 (23.8) | 4 (17.4) | 0.242 |
| Diabetes (%) | 10 (12.2) | 2 (11.1) | 1 (5.0) | 1 (4.8) | 6 (26.1) | 0.102 |
| Current smoking (%) | 12 (14.6) | 4 (22.2) | 0 | 5 (23.8) | 3 (13.0) | 0.126 |
| Antihypertensives (%) | 40 (48.8) | 10 (55.6) | 8 (40.0) | 8 (38.1) | 14 (60.9) | 0.354 |
| Diagnosis (%) | 0.039 | |||||
| Dementia | 38 (46.3) | 5 (27.8) | 6 (30.0) | 10 (47.6) | 17 (73.9) | |
| MCI | 28 (34.1) | 7 (38.9) | 7 (35.0) | 10 (47.6) | 4 (17.4) | |
| SCI | 14 (17.1) | 5 (27.8) | 6 (30.0) | 1 (4.8) | 2 (8.7) | |
| Other | 2 (2.4) | 1 (5.6) | 1 (5.0) | 0 | 0 | |
| MR scanner (% 3T)*** | 32 (39.0) | 6 (33.3) | 8 (40.0) | 9 (42.9) | 9 (39.1) | 0.944 |
| CSVD markers (%) | – | |||||
| Lacune(s) | 27 (32.9) | – | 2 (10.0) | 6 (28.6) | 19 (82.6) | |
| WMH | 40 (48.8) | – | 5 (25.0) | 14 (66.7) | 21 (91.3) | |
| CMB | 26 (31.7) | – | 5 (25.0) | 4 (19.0) | 17 (73.9) | |
| ePVS | 45 (54.9) | – | 8 (40.0) | 18 (85.7) | 19 (82.6) |
Results are presented as mean±standard deviation or number (frequency). cSVD, cerebral small vessel disease; BMI, body mass index; CVD, cardiovascular disease; MCI, mild cognitive impairment; SCI, subjective cognitive impairment; WMH, white matter hyperintensities; CMB, cerebral microbleeds; ePVS, enlarged perivascular space. * Resulting from univariate analysis of variance (continuous variables) or chi-square test (categorical variables). **Available for n = 69. ***Those not scanned on the 3T scanner were scanned on the 1.5T scanner.