Table 2.

AUCs from Disease state index classifiers differentiating between healthy controls without amyloid pathology, mild cognitive impairment with amyloid pathology and dementia patients with amyloid pathology. 95% confidence intervals are given with the mean AUC

AUC [95% CI]	Control versus Dementia	Control versus MCI	MCI versus Dementia
Total CSF + Metabolomics	0.89 [0.87–0.90]	0.84 [0.81–0.87]	0.70 [0.68–0.73]
Total CSF markers	0.87 [0.85–0.89]	0.80 [0.77–0.84]	0.64 [0.61–0.67]
Aβ42	Not included	Not included	0.65 [0.62–0.67]
tTau	0.90 [0.88–0.91]	0.82 [0.79–0.85]	0.58 [0.55–0.60]
PTau	0.78 [0.75–0.80]	0.75 [0.72–0.79]	0.49 [0.47–0.52]
Total Metabolic markers	0.73 [0.71–0.76]	0.75 [0.72–0.78]	0.68 [0.65–0.70]
Total Serum Lipids	0.71 [0.68–0.74]	0.69 [0.65–0.72]	0.61 [0.59–0.64]
Lipoproteins	0.74 [0.72–0.77]	0.72 [0.68–0.76]	0.62 [0.59–0.65]
Cholesterols	0.66 [0.63–0.69]	0.67 [0.63–0.71]	0.62 [0.59–0.65]
Glycerides and phospholipids	0.69 [0.66–0.72]	0.62 [0.58–0.66]	0.51 [0.48–0.53]
Fatty acids	0.66 [0.63–0.69]	0.66 [0.62–0.70]	0.54 [0.51–0.56]
Total Serum LMWM	0.72 [0.69–0.75]	0.64 [0.60–0.68]	0.61 [0.59–0.64]
Energy and ketone bodies	0.62 [0.59–0.65]	0.53 [0.49–0.57]	0.61 [0.58–0.63]
Amino acids	0.70 [0.67–0.73]	0.66 [0.62–0.70]	0.54 [0.51–0.57]
Total CSF LMWM	0.63 [0.60–0.66]	0.73 [0.69–0.77]	0.64 [0.62–0.67]
Energy and ketone bodies	0.55 [0.51–0.58]	0.67 [0.63–0.71]	0.62 [0.59–0.64]
Amino acids	0.65 [0.61–0.68]	0.65 [0.61–0.69]	0.58 [0.55–0.60]
Organic nitrous	0.55 [0.53–0.58]	0.69 [0.66–0.73]	0.52 [0.50–0.55]
Organosulfurs	0.61 [0.58–0.64]	0.53 [0.49–0.56]	0.53 [0.50–0.56]

Aβ₄₂, amyloid-β 42; AD, Alzheimer’s disease; AUC, area under curve; CSF, cerebrospinal fluid; LMWM, low-molecular-weight metabolites; MCI, mild cognitive impairment; pTau, phosphorylated tau; tTau, total tau.