Table 5.
Aβ Z-score | P-Tau Z-score | T-Tau Z-score | Hippocampal volume | MMSE | MCI conversion to dementia | ||||||||||||||
Sample set | protein | Linear regression | Linear regression | Linear regression | Linear regression | Linear regression | Logistic regression | ||||||||||||
β | p | q | β | p | q | β | p | q | β | p | q | β | p | q | β | p | q | ||
Oxford | |||||||||||||||||||
FCN2 | –0.19 | 0.000* | 0.000* | –0.125 | 0.017* | 0.098 | –0.138 | 0.019* | 0.132 | –244.14 | 0.000* | 0.000* | –0.88 | 0.000* | 0.000* | –0.398 | 0.002* | 0.006* | |
B2M | –00.125 | 0.001* | 0.001* | –0.019 | 0.715 | 0.876 | –0.001 | 0.991 | 0.991 | –14.6 | 0.758 | 0.758 | –0.174 | 0.183 | 0.214 | –0.039 | 0.729 | 0.901 | |
apoE | –00.123 | 0.000* | 0.001* | –0.05 | 0.334 | 0.584 | –0.045 | 0.444 | 0.778 | 00–37.388 | 0.403 | 0.470 | –0.184 | 0.146 | 0.204 | –0.015 | 0.901 | 0.901 | |
A1AT | –0.07 | 0.061 | 0.061 | –0.011 | 0.843 | 0.876 | –0.006 | 0.924 | 0.991 | –0172.168 | 0.000* | 0.001* | –0.239 | 0.078 | 0.181 | –0.096 | 0.520 | 0.901 | |
CC4 | 1–0.117 | 0.001* | 0.001* | –0.088 | 0.09 | 0.209 | –0.045 | 0.445 | 0.778 | 00–70.691 | 0.112 | 0.261 | –0.131 | 0.306 | 0.306 | –0.153 | 0.207 | 0.483 | |
Cathepsin D | 0–0.086 | 0.013* | 0.016* | –0.008 | 0.876 | 0.876 | –0.017 | 0.776 | 0.991 | –0046.917 | 0.306 | 0.429 | –0.195 | 0.118 | 0.204 | –0.032 | 0.792 | 0.901 | |
Cardiff | |||||||||||||||||||
CFI | 0*0.117 | 0.001* | 0.002* | –0.116 | 0.028* | 0.098 | –0.107 | 0.063 | 0.221 | *0052.396 | 0.256 | 0.429 | –0.442 | 0.001* | 0.002* | –0.932 | 0.000* | 0.000* |
*Statistically significant < 0.05.