Table 1.
Disease | Target gene | siRNA Type | Delivery | Reference |
---|---|---|---|---|
Con‐A hepatitis | Fas | Pre‐siRNA | IV | 40 |
Fas‐induced hepatitis | Caspase‐8 | Pre‐siRNA | IV | 77 |
Pathologic ocular angiogenesis | VEGF | Pre‐siRNA | SR | 35 |
LPS‐sepsis | TNF | Pre‐siRNA | IP | 36 |
Polyglutamine‐mediated | ||||
neuro‐degeneration | Polyglutamine repeats | Retroviral | IV | 30 |
Hepatitis B | HbsAg | Pre‐siRNA | IV | 37 |
HIV | HIV‐REV | Lentiviral | IV | 65 |
Colon cancer | Beta‐catenin | Pre‐siRNA | IV | 51 |
IV = intravenous, SR = subretinal, IP = intraperitoneal.