Table 1.

In vivo therapeutic utilization of small interfering RNA

Disease	Target gene	siRNA Type	Delivery	Reference
Con‐A hepatitis	Fas	Pre‐siRNA	IV	40
Fas‐induced hepatitis	Caspase‐8	Pre‐siRNA	IV	77
Pathologic ocular angiogenesis	VEGF	Pre‐siRNA	SR	35
LPS‐sepsis	TNF	Pre‐siRNA	IP	36
Polyglutamine‐mediated
neuro‐degeneration	Polyglutamine repeats	Retroviral	IV	30
Hepatitis B	HbsAg	Pre‐siRNA	IV	37
HIV	HIV‐REV	Lentiviral	IV	65
Colon cancer	Beta‐catenin	Pre‐siRNA	IV	51

IV = intravenous, SR = subretinal, IP = intraperitoneal.