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Generation of the hepatocyte conditional knockout (H-cKO) mouse. (A) Scheme for breeding of the H-cKO mouse through the crossing of the ST6Gal1f/f and Alb-Cre strains. (B) PCR confirmation of the genotype of the H-cKO mouse. (C) Analysis of ST6Gal1 RNA in 8–12-week-old mouse livers via quantitative PCR (qPCR) of ST6Gal1f/f and H-cKO strains demonstrated a substantial ablation of liver transcript without effects elsewhere in the mouse. Student’s T test, ***P < 0.001.
