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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Cell Metab. 2020 Apr 7;31(4):669–678. doi: 10.1016/j.cmet.2020.03.011

Figure 3.

Figure 3.

Defining a biological system helps reverse the over focus on proteins of known function.

A, There is a striking disproportionality in citations across the mitochondrial proteome.

B, After defining a high-confidence mitochondrial proteome in 2009, the distribution in citations in the top decile and bottom half have begun to shift towards a more balanced distribution.

C, While this trend is true for the mitochondrial genes, research on the rest of the genome continues to be skewed towards the more ‘popular’ proteins.