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Relationship (solid line) between 24-hour urinary free cortisol to creatinine ratio (UFC/Cr) and age in minimally adjusted model (top panel) and in the fully adjusted model (bottom panel). A significant nonlinear effect was found in which UFC/Cr decreased from in early adulthood and was stable in middle adulthood and increased thereafter (dashed lines are 95% confidence intervals). The curvilinear effect was somewhat attenuated by inclusion of covariates in fully adjusted model.
