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. 2020 Apr 22;15(4):e0231896. doi: 10.1371/journal.pone.0231896

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© 2020 Futami et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — Interactions among cancer cells, CAR T cells, and monocytes and macrophages in CRS, and therapeutic actions of PSL, TO-207, anakinra, and tocilizumab. PSL suppressed cytokine production derived from T cells and monocyte and macrophages while attenuating the cytotoxic effects of CAR T cells, whereas TO-207 suppressed monokine production without disturbing the cytotoxic effects of CAR T cells. Anakinra and tocilizumab did not exert suppressive effects on cytokines other than their specific targets.