Table 14.1.

Organs and cell types infected by SARS-CoV

	Organs
	Lung	Kidney	Liver	Brain	Intestine	Immune system
Detection of SARS-CoV	ISH, EM, RT-PCR	ISH, EM	RT-PCR	EM, RT-PCR	ISH, EM, RT-PCR	EM, ISH
Cell types	Pneumocyte, endothelial and epithelial cells, macrophage, lymphocyte	Epithelial cells of renal tubules	Hepatocyte	Neurons of cortex and hypothalamus	Epithelial cells of mucosa	Monocyte, lymphocyte, macrophage in lymph node, spleen
Tissue damage	+	+	+	+	−	+
Cell death	Apoptosis, necrosis	Necrosis	Apoptosis	Necrosis	No tissue damage	Necrosis

+ positive; − negative; ISH: In situ hybridization; RT-PCR: Reverse-transcription polymerase chain reaction; EM: Electronic microscopy