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. 2020 Apr 10;16(4):e1007778. doi: 10.1371/journal.pcbi.1007778

Table 3. Rejection rates.

q = 13. 1000 iterations. α = 0.05. Same subjects for two traits. For CMC, B = 103. Colocalization = No: type I errors for JLIM and conditional, power for coloc. Colocalization = Yes: power for JLIM and conditional, type I errors for coloc. For MA, B = 103, u = 10 and s = 1.

Colocalization Causal locations for trait 1 (size) Causal locations for trait 2 (size) JLIM Conditional coloc HEIDI
1st SNP CB CMC MA
No 1 (0.3) None 0.042 0.057 0.002 0.030 0.032 0.029 0.164 (0.027)
1 (0.3) 4 (0.3) 0 0.057 0.004 0.035 0.041 0.954 0.012 (0.011)
1 (0.2), 5 (-0.3) 4 (0.3) 0.395 0.040 0.004 0.029 0.028 0.849 0.040 (0.034)
Yes 1 (0.2) 1 (0.2) 0.980 0.815 0.439 0.621 0.680 0.001 0.017 (0.014)
1 (0.2) 1 (0.2), 4 (0.4) 0.013 0.815 0.439 0.584 0.655 0.292 0.006 (0.006)