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. 2020 Apr 10;16(4):e1007778. doi: 10.1371/journal.pcbi.1007778

Table 4. Rejection rates.

1000 iterations. α = 0.05. Same subjects for two traits. For CMC, B = 103. τ = 0.2. Regions A1-A2: without colocalization (type I errors for JLIM and conditional, power for coloc). Regions B1-B6: with colocalization (power for JLIM and conditional, type I errors for coloc). For MA, B = 103, u = 10. s = 3 for loci with more than 50 SNPs, s = 2 otherwise.

Region # SNPs
(*)
JLIM Conditional coloc
1st SNP CB CMC MA
A1 43 (2/0/0) 0.039 0.011 0 0.014 0.026 0.027
A2 58 (17/2/0) 0.054 0.010 0.010 0.030 0.046 0.047
B1 28 (9/4/1) 0 0.018 0.189 0.276 0.288 1
B2 53 (7/18/2) 0 0.005 0.429 0.542 0.581 1
B3 62 (12/6/2) 0.724 0.011 0.546 0.721 0.739 1
B4 43 (18/10/5) 0 0.009 0.154 0.238 0.281 1
B5 43 (9/7/6) 0.179 0.016 0.683 0.859 0.877 1

(*) Numbers of SNPs that are causal for trait 1 / trait 2 / both traits.