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. 2019 Jan 24;40(5):881–890. doi: 10.1097/IAE.0000000000002470

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Fig. 2. — Multimodal OCT-based imaging of the right eye of a patient with exudative age-related macular degeneration immediately before, 1 week, and 1 month after IVA injection. Optical coherence tomography leakage map of the full retina scan in the 1st row shows the extension of fluid accumulation and its change during follow-up. This change took place mainly in the OS and RPE–Bruch layers (2nd and 3rd rows). One can see a steady decrease in fluid distribution in the OS layer; however, in RPE–Bruch layer, there seems to be more fluid in 1st month compared with the 1st week. Accordingly, the conventional B-scans show a decrease in subretinal fluid, but the fibrovascular PED seems to increase again after 1 month (6th row). The OCTA analysis also shows a decrease in vascularization of the CNV after 1 week; however, there is repermeabilization of the vascular network in the Month 1, with a flow signal similar to baseline (4th row). Association of noninvasive OCTA and OCT-L thus show structural changes occurring before significant RT change and provide insight into a case that might need early retreatment to control the exudative membrane. Optical coherence tomography leakage segmentation used in the layers depicted is marked in white in the SD-OCT images. Optical coherence tomography angiography segmentation was customized for better visualization of the neovascular network.