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. 2020 Apr 15;11:532. doi: 10.3389/fmicb.2020.00532

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Copyright © 2020 Sagheddu, Uggeri, Belogi, Remollino, Brun, Bernabè, Moretti, Porzionato, Morelli, Castagliuolo and Elli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactobacillus reuteri LMG P-27481 induces an anti-inflammatory cytokine profile in human dendritic cells. The DCs obtained from differentiated peripheral blood monocytes were incubated (1:10 ratio) with the reported live bacterial strains for 1 h in medium without antibiotics. The cells were then collected, washed by centrifugation and incubated for an additional 23-h period in complete medium with antibiotics. Culture supernatants were collected. (A) IL-10 content quantified by ELISA. (B) IL-12p70 concentration assessed by ELISA. (C) Shows the anti-inflammatory index calculated as the ratio between IL-10 and IL-12p70 listed in Panels (A,B). Data are reported as mean ± SD on values obtained on 3 different donors. *P < 0.05 versus control and °P < 0.05 versus LMG P-27481.