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. 2020 Apr 15;11:652. doi: 10.3389/fmicb.2020.00652

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Copyright © 2020 Guo, Huang, Hu, Chen, Huang, Liu, Wang, Zhu, Zhao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap was applied to visualize the differences in the composition of metabolites among different groups. (A) Metabolites mainly related to benzene, phenols and indoles; (B) Metabolites mainly related to polyketides and prenol lipids. Microbial metabolite concentration was scaled with log transformation in the heatmap. 1, cluster 1 represents a significant down-regulated at CN10 and CN15, compared to those at CN6; 2, cluster 2 represents a slightly up-regulated at CN10 and a significantly increased at CN15, compared to those at CN6; 3, cluster 3 represents those with low concentrations in the groups Ori (Day 0) and CN6, but they have high concentrations in the groups CN10 or CN15.