TABLE 2.

Features shared by the potential abyssomicin BGCs described in this study.

Cluster type	Shared motifs
1a	Upstream the PKS genes:
	Entire abyA1-A5 operon next to/nearby abyU which in most cases is located next to abyK, abyH and abyI.
	Downstream the PKS genes:
	Synteny is maintained from abyC to abyW with punctual rearrangements.
1b	Same conserved blocks as type 1a clusters but all genes are upstream the PKS genes.
	Extra copy of abyV downstream the PKS.
2a	Upstream the PKS genes:
	Presence of abyA1-A5 operon except abyA2 followed by abyN.
	Downstream the PKS genes:
	Synteny is maintained from abyA2 to abyI with punctual rearrangements.
2b	Same conserved blocks as type 2a clusters but all genes are upstream the PKS genes except abyA2.
3	Entire abyA1-A5 operon followed by abyT.
	ABC transport system divided by the presence of abyM.
4	abyZ, abyA3 and abyA2 are located upstream the first PKS gene.
	The PKS operon harbors between abyB1 and abyB2 a set of genes that includes at least abyA1 and abyU.
5	No synteny between themselves nor with other cluster types.