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. 2020 Apr 20;133(8):951–958. doi: 10.1097/CM9.0000000000000747

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Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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The major mechanisms regulated by CKLF1 in autoimmune diseases. CKLF1 may mediate the immune inflammatory reaction process in LN; CKLF1 may promote development and progression of the inflammatory response and neo-angiogenesis and inhibit cartilage cell proliferation in RA; CKLF1 may promote the proliferation of endothelial cells, participate in local inflammation and dysregulate the function of psoriatic skin cells. CCR4: C-C chemokine receptor 4; CKLF: Chemokine-like factor; ERK: Extracellular signal-regulated kinase; IFN: Interferon; IL: Interleukin: MAPK: Mitogen-activated protein kinase; PMNs: Polymorphonuclear leukocytes; LN: Lupus nephritis; Th: T helper cells; RA: Rheumatoid arthritis; TNF: Tumor necrosis factor.