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. 2020 Apr 21;14(2):024114. doi: 10.1063/1.5144617

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Copyright © 2020 Author(s)

Published under license by AIP Publishing.

1932-1058/2020/14(2)/024114/10/$30.00

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FIG. 4. — (a) Effect of microbubble concentrations on ultrasound-mediated fluorescein uptake. There was a trend toward statistical significance (ANOVA p = 0.12, n = 4/group). (b) Effect of peak negative acoustic pressure on ultrasound-mediated fluorescein uptake. There were statistically significant differences with ultrasound pressures at 0.5 and 0.9 MPa compared to the 0 MPa (no ultrasound) control group (ANOVA p = 0.01, n = 4–7/group). (c) Effect of pulse interval on ultrasound-mediated fluorescein uptake. There were no statistically significant differences between the different pulse intervals (n = 4–5/group). (d) Effect of microfluidic flow rate on ultrasound-mediated fluorescein uptake, ultrasound treatment, and flow rate effect fluorescein uptake, respectively (p < 0.05, n = 5/group).