Table 5.
Factors Predicting Symptom Improvement With Mosapride Treatment
| Variables | Responders (n = 15) | Non-responders (n = 6) | Univariated analysis P-valuea | Multivariated analysis P-valueb | Adjusted OR (95% CI)b |
|---|---|---|---|---|---|
| Age (yr) | 55.0 (49.0-60.0) | 55.5 (39.5-60.3) | 0.970 | 0.243 | 0.94 (0.85-1.04) |
| Female | 7 (46.7) | 1 (16.7) | 0.221 | 0.758 | 1.65 (0.07-39.72) |
| BMI (kg/m2) | 22.9 (21.5-26.7) | 22.2 (20.2-27.8) | 0.850 | - | - |
| Smoking (current + previous) | 5 (33.3) | 3 (50.0) | 0.410 | - | - |
| Alcohol (current + previous) | 12 (80.0) | 5 (83.3) | 0.684 | - | - |
| Reflux esophagitis, LA grade A | 2 (13.3) | 1 (16.7) | 0.658 | - | - |
| Hiatal hernia | 2 (13.3) | 1 (16.7) | 0.658 | - | - |
| Fragmented peristalsis | 5 (33.3) | 1 (16.7) | 0.424 | 0.220 | 14.38 (0.20-1021.30) |
| WHOQOL-BREF baseline score | |||||
| Total | 85.0 (72.0-95.0) | 79.0 (65.3-83.3) | 0.302 | - | - |
| Overall quality of life | 6.0 (5.0-7.0) | 5.5 (4.8-6.3) | 0.569 | - | - |
| Physical health | 22.0 (19.0-24.0) | 21.5 (16.5-23.3) | 0.519 | - | - |
| Psychological health | 19.0 (16.0-21.0) | 16.5 (12.8-19.0) | 0.178 | - | - |
| Social relationships | 11.0 (9.0-12.0) | 10.5 (8.8-12.0) | 0.677 | - | - |
| Environmental quality of life | 26.0 (22.0-29.0) | 23.5 (20.0-27.5) | 0.302 | - | - |
| HRM metrics | |||||
| Esophageal length (cm) | 27.1 (26.9-28.1) | 28.8 (27.0-30.3) | 0.132 | - | - |
| LES length (cm) | 2.8 (2.7-3.2) | 2.8 (2.3-3.4) | 0.677 | - | - |
| LES respiratory mean pressure (mmHg) | 16.0 (8.9-25.7) | 8.7 (8.0-11.0) | 0.036 | 0.112 | 1.18 (0.96-1.46) |
| LES residual pressure (mmHg) | 5.3 (1.5-9.3) | 3.2 (2.2-4.0) | 0.381 | 0.892 | 1.05 (0.49-2.26) |
| Effective swallows (%) | 50.0 (30.0-80.0) | 50.0 (30.0-75.0) | 0.910 | - | - |
| DCI (mmHg·sec·cm) | 338.0 (288.8-1177.0) | 375.8 (115.9-440.5) | 0.444 | 0.376 | 1.00 (0.99-1.01) |
| Intrabolus pressure (mmHg) | –0.7 (–2.4-2.6) | –0.8 (–2.7-2.4) | 0.841 | - | - |
a
Variables were compared using the non-parametric Fisher’s exact test or Mann-Whitney test and a P-value < 0.05 was considered significant.
b
Logistic model including terms of age, sex, subtypes of minor peristaltic disorders, lower esophageal sphincter (LES) respiratory mean pressure, LES residual pressure, and distal contractile integral (DCI).
OR, odds ratio; CI, confidence interval; BMI, body mass index; LA, Los Angeles; WHOQOL-BREF, World Health Organization quality of life scale abbreviated version; HRM, high-resolution manometry.
Variables are presented as median (interquartile range) or number (%).