Table 3.
Comparison of Tight Junction Protein mRNA Expression Levels Between Control and Functional Dyspepsia Groups in Helicobacter pylori Uninfected Subjects
| Tight junction protein | Control (n = 30) | FD (n = 58) | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Total (n = 30) | Male (n = 15) | Female (n = 15) | Total (n = 58) | Male (n = 23) | Female (n = 35) | Control vs FD | Control (male vs female) | FD (male vs female) | |
| CLDN1 | 0.8 (0.5-1.5) | 0.8 (0.4-3.4) | 0.8 (0.5-1.3) | 1.0 (0.7-1.6) | 1.5 (0.7-2.8) | 0.9 (0.6-1.2) | 0.369 | 0.513 | 0.014 |
| CLDN2 | 0.9 (0.5-1.1) | 0.6 (0.2-1.0) | 1.1 (0.6-1.5) | 1.5 (0.7-2.3) | 1.3 (0.8-1.9)a | 1.6 (0.6-2.5) | 0.009 | 0.037 | 0.591 |
| CLDN4 | 1.1 (0.3-1.6) | 1.1 (0.2-2.3) | 1.3 (0.4-1.5) | 1.5 (1.0-1.8) | 1.6 (1.2-1.9) | 1.4 (0.7-1.8) | 0.075 | 0.713 | 0.413 |
| OCLN | 0.7 (0.5-1.7) | 0.7 (0.5-1.2) | 1.0 (0.5-2.4) | 1.0 (0.6-2.4) | 1.3 (0.8-3.6) | 1.0 (0.5-1.5) | 0.446 | 0.649 | 0.113 |
| ZO-1 | 4.1 (0.4-10.9) | 7.4 (1.4-13.8) | 1.5 (0.3-7.6) | 1.0 (0.2-5.6) | 1.9 (0.5-7.1) | 0.7 (0.2-5.2) | 0.118 | 0.648 | 0.147 |
a
Statistically significant compared to male control group.
FD, functional dyspepsia; CLDN, claudin; OCLN, occludin; ZO-1, zonula occludens-1.
Data are presented as median (interquartile range).