Table 2.
The Mean Difference in Severity Score (Global Overall Symptom Scale) Between Groups
| Symptom | Clidinium/chlordiazepoxide (n = 37) | Placebo (n = 36) | P-values | ||||
|---|---|---|---|---|---|---|---|
| Baseline (mean ± SD) | Week 4 (mean ± SD) | Mean difference (95% CI) | Baseline (mean ± SD) | Week 4 (mean ± SD) | Mean difference (95% CI) | ||
| Overall symptoms | 32.30 ± 7.22 | 16.51 ± 5.58 | –15.78 (–18.24, –13.33) | 31.53 ± 7.64 | 26.75 ± 10.50 | –4.78 (–7.43, –2.13) | < 0.001 |
| Epigastric pain | 4.89 ± 1.52 | 2.51 ± 1.17 | –2.38 (–2.83, –1.93) | 5.00 ± 1.55 | 4.14 ± 1.84 | –0.86 (–1.34, –0.38) | < 0.001 |
| Epigastric burning | 4.62 ± 1.74 | 2.08 ± 0.95 | –2.54 (–3.10, –1.98) | 3.72 ± 2.08 | 3.33 ± 2.19 | –0.39 (–0.78, 0.00) | < 0.001 |
| Heartburn or regurgitation | 4.76 ± 1.79 | 2.32 ± 1.16 | –2.43 (–3.02, –1.85) | 4.91 ± 1.36 | 3.89 ± 1.85 | –1.03 (–1.58, –0.48) | 0.001 |
| Early satiety | 3.27 ± 1.97 | 1.76 ± 1.12 | –1.51 (–2.07, –0.96) | 3.36 ± 1.93 | 2.83 ± 1.70 | –0.53 (–0.94, –0.11) | 0.005 |
| Nausea | 2.57 ± 1.90 | 1.38 ± 0.79 | –1.19 (–1.73, –0.65) | 2.56 ± 1.71 | 2.22 ± 1.62 | –0.33 (–0.67, 0.00) | 0.008 |
| Belching | 4.32 ± 1.75 | 2.57 ± 1.39 | –1.76 (–2.28, –1.23) | 4.78 ± 1.49 | 4.03 ± 1.63 | –0.75 (–1.16, –0.34) | 0.003 |
| Postprandial fullness | 4.30 ± 1.76 | 2.16 ± 1.26 | –2.14 (–2.65, –1.62) | 4.08 ± 1.70 | 3.64 ± 1.71 | –0.44 (–0.87, –0.02) | < 0.001 |
| Epigastric bloating | 3.57 ± 2.05 | 1.73 ± 0.99 | –1.84 (–2.41, –1.263) | 3.11 ± 2.14 | 2.67 ± 2.03 | –0.44 (–0.88, –0.01) | < 0.001 |