Table 6.

Summary of the Evidence Supporting Peroral Endoscopic Myotomy in Patients With Type III Achalasia

Study	Country	Study design	Participants	Intervention	Comparator	Follow-up duration	Outcome
2015, Kumbhari et al92	International (4 USA, 3 Asian, and 1 European centers)	Retrospective cohort study	Type 3 achalasia patients who underwent POEM or LHM	POEM, n = 49	LHM, n = 26	POEM, mean 8.6 mo; LHM, mean 21.5 mo	Median procedure time, min: POEM, 102 (43-345); LHM, 264 (189-331)Clinical response rate: POEM, 98.0% (n = 48); LHM, 80.8% (n = 21)
2017, Khan et al95	USA	Meta-analysis	Eight studies on type 3 achalasia patients who underwent POEM	POEM, n = 179	None	Range, 3 mo-3 yr	Clinical success rate (8 studies): 91.6% (95% CI, 84.3-95.7%)Adverse event rate (8 studies): 11.2% (95% CI, 6.3-19.0%)

POEM, peroral endoscopic myotomy; LHM, laparoscopic Heller myotomy; CI, confidence interval.