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. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: Neuroscience. 2020 Mar 27;434:136–147. doi: 10.1016/j.neuroscience.2020.03.037

Fig. 8. GHR ablation in AgRP-expressing cells reduces the projections of AgRP neurons without affecting POMC projections.

Fig. 8.

A. Number of AgRP neurons in the ARH of control (n = 3) and AgRP GHR KO (n = 3) mice. B. Number of POMC neurons in the ARH of control (n = 5) and AgRP GHR KO (n = 5) mice. C. Hypothalamic mRNA levels of Mc3r and Mc4r in control (n = 8) and AgRP GHR KO (n = 8) mice. D-F. Quantification of POMC fiber density in the PVH (A), LHA (B) and DMH (C) of control (n = 5–6) and AgRP GHR KO (n = 5–6) mice. G-I. Quantification of AgRP fiber density in the PVH (D), LHA (E) and DMH (F) of control (n = 5) and AgRP GHR KO (n = 5) mice. Mean ± s.e.m. Two-tailed Student’s t-test. * P < 0.05 vs. AgRP GHR KO.