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. 2020 Mar 2;39(17):3541–3554. doi: 10.1038/s41388-020-1237-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a A heatmap demonstrates the hierarchical clustering using the top 1000 variable genes in 1030 SCC patients. The color bar and legend show the primary site of the tumor. b The distribution of clusters L and R per tumor type stratified by histological types is shown. c PCA using the variable 1000 genes of 1030 SCC patients is shown. The color and legend in each plot show the primary site of the tumor. d Box plots show ssGSEA score of epidermis development and skin development in different SCCs. e Box plots show log2 TPM of KRT1 and KRT18 in different SCCs. f Pie charts show the number and percentage of CK1/CK18 protein expression evaluated by using immunohistochemistry in 21 MCT-SCCs.