Table 1.
Clinical characteristics of 27 carcinomas arising from mature cystic teratoma of the ovary.
| Sample ID | Sequencing platform | Age (year) | FIGO Stage | Histology | Classification | Epithelium adjacent to cancer site | SCC ag (ng/ml) | Tumor size (mm) | Treatment | Reccurent site | Follow up (Month) | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | Exome seq and RNA seq | 69 | IIB | SCC | Keratinizing | NOS | 4.9 | 120 | Surgery, CT | No | 79 | Alive |
| #2 | Exome seq and RNA seq | 53 | IA | SCC | Nonkeratinizing | NOS | 2 | 165 | Surgery, CT | No | 72 | Alive |
| #3 | Exome seq and RNA seq | 62 | IIIC | SCC | Nonkeratinizing | NA | 82.2 | 150 | Surgery, CT | Abdominal dissemination | 7 | Dead |
| #4 | Exome seq and RNA seq | 59 | IIB | SCC | Keratinizing | NOS | 1.1 | 126 | Surgery, CT | No | 14 | Alive |
| #5 | Exome seq and RNA seq | 49 | IIIA | ASC | Nonkeratinizing | Skin | 178.2 | 209 | Surgery, CT | Lympho node | 17 | Alive |
| #6 | Target seq | 48 | IC | SCC | Keratinizing | NOS | 1.5 | 108 | Surgery, CT | No | 92 | Alive |
| #7 | Target seq | 60 | IA | SCC | Keratinizing | NOS | 2.1 | 102 | Surgery, CT | No | 28 | Alive |
| #8 | Target seq | 63 | IC | SCC | Keratinizing | Skin | 13.6 | 136 | Surgery | No | 15 | Alive |
| #9 | Not done | 54 | IVB | SCC | Keratinizing | NA | 27.3 | 130 | Surgery, CT | Lympho node, Lung | 34 | Dead |
| #10 | Not done | 55 | IA | SCC | Nonkeratinizing | NA | 6.6 | 130 | Surgery, CT | No | 79 | Dead |
| #11 | Not done | 53 | IA | SCC | Nonkeratinizing | Skin | 14.3 | 120 | Surgery | Skin | 62 | Alive |
| #12 | Not done | 70 | IIA | SCC | Nonkeratinizing | NOS | 5.4 | 170 | Surgery | Lympho node, Liver | 3 | Dead |
| #13 | Not done | 60 | IA | SCC | Nonkeratinizing | NA | <1 | 90 | Surgery, CT | Lung | 24 | Dead |
| #14 | Not done | 38 | IIIC | SCC | Keratinizing | NA | 12 | 200 | Surgery, CT | Abdominal dissemination | 3 | Alive |
| #15 | Not done | 33 | IA | SCC | Keratinizing | NA | 2.4 | NA | Surgery | No | 64 | Alive |
| #16 | Not done | 79 | IIIC | SCC | Keratinizing | NA | 9.9 | 100 | Surgery | Abdominal dissemination | 4 | Dead |
| #17 | Not done | 79 | IIIC | ASC | Keratinizing | Skin | 3.5 | 150 | Surgery, CT | No | 8 | Dead |
| #18 | Not done | 36 | IIIC | ASC | Nonkeratinizing | NA | 1.7 | 137 | Surgery | Abdominal dissemination | 2 | Dead |
| #19 | Not done | 53 | IA | SCC | Nonkeratinizing | NA | 8.9 | 150 | Surgery | No | 115 | Alive |
| #20 | Not done | 70 | IIIC | SCC | Keratinizing | NA | 14.2 | 192 | Surgery | NA | 3 | Alive |
| #21 | Not done | 58 | IIIC | SCC | Keratinizing | Skin | 2252.6 | 153 | Surgery, CT | Abdominal dissemination Pleural effusion, ascites | 3 | Dead |
| #22 | Not done | 53 | IC | SCC | Keratinizing | NA | 2.5 | 296 | Surgery, CT | NA | 6 | Alive |
| #23 | Not done | 60 | IC | SCC | Nonkeratinizing | NOS | 1.2 | 88 | Surgery, CT | No | 156 | Alive |
| #24 | Not done | 73 | IA | SCC | Nonkeratinizing | Skin | 3.5 | 150 | Surgery | No | 94 | Alive |
| #25 | Not done | 66 | IA | SCC | Keratinizing | Skin | 2.5 | 296 | Surgery | No | 80 | Alive |
| #26 | Not done | 46 | IA | SCC | Nonkeratinizing | NA | 0.9 | 67 | Surgery | No | 3 | Alive |
| #27 | RNA seq | 79 | IA | AC | NA | NA | 9.9 | 100 | Surgery | No | 24 | Alive |
SCC squamous cell carcinoma, ASC adenosquamous carcinoma, AC adenocarcinoma, NOS not otherwise specified, NA not available, CT chemotherapy.