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. 2020 Feb 28;39(17):3507–3521. doi: 10.1038/s41388-020-1227-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Protein and b mRNA expression of EMT markers in the cells treated with FGF19-EV or FGF19-OE for 48 h in SK-MES-1 cells. c Analysis of correlation between CDH2 and FGF19 from Oncomine TCGA datasets. The images of migration abilities in FGF19-OE transfected cells in trans-well (d) and wound healing (e) assays, respectively. f Overexpression of FGF19 increased tumor growth in vivo in orthotopic lung cancer models. Representative image of primary tumors in the left lungs of orthotropic models on day 21 from each group after implantation of SK-MES-1 cells transfected with FGF19-OE and FGF19-EV. g Metastatic tumors in other organs. h Representative images of IHC analysis of Ki-67 expression in lung and tumors. Right panel: Quantification of Ki-67 expression. i (a) Evaluation of FGF19 expression in serum samples from two groups. (b) Mean primary tumor body weight and (c) survival curve for the mice in each treatment group evaluated. j Within the 57 NSCLC patients’ group, the serum levels of FGF19 in patients with metastasis (n = 34) were shown side by side with those of patients without metastasis (n = 23). Data are represented as mean and SEM from three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001.