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. 2020 Apr 22;10:6805. doi: 10.1038/s41598-020-63311-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FIR treatment changes gene expression in FIR-responsive and FIR-non/unresponsive male and female CAD ECFCs. (A) Summary of RNA-seq data. FIR-responsive and FIR-non/unresponsive CAD ECFCs were treated with FIR. 24 hours after FIR treatment, total RNA was extracted and used for RNA-seq on Illumina HiSeq2500. Reads Per Kilobase per Million mapped reads (RPKM) higher than 1 in at least one sample were considered as expressed genes and used for fold-change calculations. Venn diagram showing the mRNAs that are up- or down-regulated more than 1.5 fold by FIR treatment. Blue (Male) and Pink (Female). Boldface (FIR-responsive) and Light face (FIR-non/unresponsive). (B) Heatmap of hierarchical cluster analysis of mRNAs simultaneously up- (151) and down-(50) regulated in FIR-responsive male and female CAD ECFCs after FIR treatment.