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. 2020 Apr 22;10:6836. doi: 10.1038/s41598-020-63808-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A–C) Cell viability of MB cell lines after treatment with ATO. The assay was carried out for 24, 48, 72, 96 and 120 hours at concentrations of 1, 2, 4, 8 and 16 μM; (D–F) ATO radiosensitizing effects in MB cell lines. Cells were treated with ATO 0.5 μM for 48 hours, then they were submitted to radiation at different doses and maintained under standard culture conditions for 7-9 days before colonies analyses; (G) Apoptosis rates in UW402, DAOY and ONS-76 cell lines after treatment with ATO (2, 4 or 8 μM) for 48 hours. Cells labeled with annexin and with annexin plus PI were considered; (H) Clonogenic capacity assay. Survival fraction of UW402, DAOY and ONS-76 cell lines after treatment with ATO for 48 hours at concentrations of 0.5, 1, 2 and 4 μM. Colonies containing at least 50 cells were considered. Statistical analysis was carried out using one-way ANOVA and Bonferroni post-test. (*) represents p < 0.05. The data reported are representative of three independent experiments.