Table 2.
The TOP relative proteins ranked by the involved signaling pathway numbers.
| Uniprot Entry ID | KBD vs. OA | Gene | Protein | Pathway name |
|---|---|---|---|---|
| L7RXH5 | down | MAPK3 | Mitogen-activated protein kinase | Cellular senescence; Autophagy; Insulin signaling pathway; Regulation of actin cytoskeleton; Phospholipase D signaling pathway; Estrogen signaling pathway; Osteoclast differentiation; MAPK signaling pathway; Toll-like receptor signaling pathway; Th1 and Th2 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; Adherens junction; IL-17 signaling pathway; Proteoglycans in cancer; Chemokine signaling pathway; TNF signaling pathway; Signaling pathways regulating pluripotency of stem cells; VEGF signaling pathway; GnRH signaling pathway; Apoptosis; Focal adhesion; TGF-beta signaling pathway; NOD-like receptor signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; mTOR signaling pathway; cAMP signaling pathway; T cell receptor signaling pathway; |
| Q04206 | up | RELA | Transcription factor p65 | Cellular senescence; Mitophagy; Osteoclast differentiation; Fluid shear stress and atherosclerosis; MAPK signaling pathway; Toll-like receptor signaling pathway; Th1 and Th2 cell differentiation; AGE-RAGE signaling pathway in diabetic complications; NF-kappa B signaling pathway; IL-17 signaling pathway; Chemokine signaling pathway; TNF signaling pathway; Apoptosis; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; HIF-1 signaling pathway; cAMP signaling pathway; Th17 cell differentiation; T cell receptor signaling pathway; |
| A0A1W6S962 | down | GTF2I | GTF2I-BRAF fusion protein | Insulin signaling pathway; Regulation of actin cytoskeleton; MAPK signaling pathway; Proteoglycans in cancer; Vascular smooth muscle contraction; Natural killer cell mediated cytotoxicity; Focal adhesion; Rap1 signaling pathway; mTOR signaling pathway; cAMP signaling pathway; |
| P40763 | down | STAT3 | Signal transducer and activator of transcription 3 | AGE-RAGE signaling pathway in diabetic complications; Proteoglycans in cancer; Signaling pathways regulating pluripotency of stem cells; HIF-1 signaling pathway; Jak-STAT signaling pathway; Th17 cell differentiation; |
| D9ZGF8 | down | ROCK1 | Rho-associated protein kinase | Regulation of actin cytoskeleton; Proteoglycans in cancer; Focal adhesion; TGF-beta signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Tight junction; |
| L7UUZ7 | down | ITGB3 | Integrin beta | Regulation of actin cytoskeleton; Phagosome; Proteoglycans in cancer; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; Rap1 signaling pathway; |
| P63218 | down | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | Chemokine signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; GABAergic synapse; |
| P02462 | down | COL4A1 | Collagen alpha-1(IV) chain | AGE-RAGE signaling pathway in diabetic complications; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| P56199 | down | ITGA1 | Integrin alpha-1 | Regulation of actin cytoskeleton; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| P08123 | down | COL1A2 | Collagen alpha-2(I) chain | AGE-RAGE signaling pathway in diabetic complications; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| P02452 | down | COL1A1 | Collagen alpha-1(I) chain | AGE-RAGE signaling pathway in diabetic complications; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| P11233 | down | RALA | Ras-related protein Ral-A | Ras signaling pathway; Rap1 signaling pathway; |
| P24043 | up | LAMA2 | Laminin subunit alpha-2 | ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| Q15904 | up | ATP6AP1 | V-type proton ATPase subunit S1 | Rheumatoid arthritis; Oxidative phosphorylation; Metabolic pathways; Phagosome; Lysosome; |
| P08138 | up | NGFR | Tumor necrosis factor receptor superfamily member 16 | MAPK signaling pathway; PI3K-Akt signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Apoptosis - multiple species; |
| P49746 | up | THBS3 | Thrombospondin-3 | Phagosome; ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; |
| P35443 | up | THBS4 | Thrombospondin-4 | Phagosome; ECM-receptor interaction; Focal adhesion; PI4K-Akt signaling pathway; |