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. 2020 Apr 22;10:6825. doi: 10.1038/s41598-020-63818-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose reduction factor (DRF) determination. Mice were administered either FB or BBT-059 (0.3 mg/kg) 24 h prior to TBI at various doses. Radiation doses for the FB group were 7.5, 8.0, 8.5, 9.0, 9.5, and 10 Gy and radiation doses for the BBT-059 were 10.5, 11.0, 11.5, 11.75, 12.0, and 12.5 Gy. Probit analysis was conducted for each group and LD50/30 values of 9.25 and 11.81 Gy were determined for the groups administered FB and BBT-059 respectively. This ratio, BBT-059/FB gives a DRF value of 1.28 with a 95% confidence interval of 1.14–1.57. n = 24 mice per group.