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. 2020 Apr 22;10:6825. doi: 10.1038/s41598-020-63818-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lung histology demonstrates cholesterol clefts and Histiocytes. Differences between the histiocytic pneumonitis and the normal lungs. These photos of lungs taken at 40× magnification at the objective (total 400×) Photos BBT-059 11.5–6 M, BBT-059 11.5–12 M; and BBT-059 12–6 M; all show histiocytic pneumonitis. The large “foamy” cells identified with arrows are all histiocytes. The yellow arrow identifies a “cholesterol cleft”. They commonly occur in areas of the lungs with these foamy macrophages, often in association with a lot of proteinaceous material. Please note, it is possible that the histiocytic pneumonitis is simply a background lesion that would have occurred in these animals regardless of exposure.