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. 2020 Apr 22;10:6825. doi: 10.1038/s41598-020-63818-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Radiation-induced cellular senescence in kidney. Increased numbers of senescence-associated β-galactosidase (SA β-gal)-positive cells in the kidneys administered FB or BBT-059 24 h prior to irradiation at the highest radiation dose (12.5 Gy). Kidneys isolated from mice at 1, 6 and 12 months were stained for SA β-gal. Cells stained blue are positive for SA β-gal. Significant differences are indicated (*p < 0.05). Scale bars = 20 µm.