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. 2020 Apr 22;10:6799. doi: 10.1038/s41598-020-63825-8

Table 2.

Unadjusted and adjusted analysis examining the correlations between low density lipoprotein cholesterol levels and the primary and secondary outcomes in ST elevation myocardial infarction (STEMI) and Non-ST elevation myocardial infarction (NSTEMI) patients who underwent percutaneous coronary intervention.

All STEMI + NSTEMI patients All STEMI + NSTEMI patients discharged alive
Death during hospitalization Death within 30 days from MI onset Death within 1 year from MI onset Rehospitalization for HF within 1 year from MI discharge Rehospitalization for MI within 1 year from MI discharge
HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI) p
Unadjusted
LDL-C in mmol/l 0.77 (0.74–0.80) <0.001 0.65 (0.62–0.68) <0.001 0.68 (0.66–0.70) <0.001 0.97 (0.90–1.04) 0.411 0.95 (0.89–1.03) 0.220
Ordinal categories
<1.8 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
1.8–2.5 0.68 (0.60–0.78) <0.001 0.52 (0.46–0.58) <0.001 0.58 (0.53–0.62) <0.001 0.90 (0.68–1.19) 0.451 1.05 (0.76–1.44) 0.783
2.6–3.3 0.56 (0.49–0.65) <0.001 0.37 (0.32–0.42) <0.001 0.40 (0.36–0.44) <0.001 0.95 (0.72–1.25) 0.719 1.04 (0.76–1.42) 0.821
3.4–4.0 0.45 (0.38–0.53) <0.001 0.26 (0.22–0.30) <0.001 0.29 (0.26–0.32) <0.001 0.76 (0.56–1.03) 0.078 0.86 (0.61–1.22) 0.402
4.1–4.8 0.47 (0.38–0.58) <0.001 0.25 (0.21–0.31) <0.001 0.26 (0.23–0.30) <0.001 0.77 (0.55–1.08) 0.130 0.89 (0.61–1.30) 0.553
≥4.9 0.37 (0.29–0.48) <0.001 0.22 (0.15–0.33) <0.001 0.32 (0.28–0.37) <0.001 0.95 (0.66–1.36) 0.775 0.88 (0.57–1.34) 0.543
Adjusted*
LDL in mmol/l 0.81 (0.76–0.87) <0.001 0.79 (0.74–0.85) <0.001 0.88 (0.84–0.91) <0.001 1.01 (0.93–1.10) 0.795 0.98 (0.88–1.08) 0.640
Ordinal categories
<1.8 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
1.8–2.5 0.72 (0.60–0.86) <0.001 0.62 (0.52–0.73) <0.001 0.77 (0.68–0.86) <0.001 0.83 (0.59–1.16) 0.281 1.14 (0.76–1.70) 0.519
2.6–3.3 0.62 (0.50–0.76) <0.001 0.54 (0.44–0.66) <0.001 0.66 (0.58–0.76) <0.001 0.97 (0.69–1.36) 0.854 1.32 (0.87–2.01) 0.190
3.4–4.0 0.56 (0.43–0.72) <0.001 0.46 (0.36–0.59) <0.001 0.63 (0.53–0.73) <0.001 0.95 (0.65–1.40) 0.801 1.01 (0.63–1.61) 0.968
4.1–4.8 0.60 (0.43–0.82) 0.002 0.53 (0.40–0.70) <0.001 0.66 (0.55–0.80) <0.001 0.82 (0.53–1.27) 0.381 1.03 (0.62–1.73) 0.899
≥4.9 0.48 (0.34–0.70) <0.001 0.45 (0.32–0.63) <0.001 0.68 (0.55–0.85) <0.001 1.12 (0.71–1.76) 0.638 1.03 (0.57–1.84) 0.930

*Adjusted for: oral medication for hyperlipidemia (yes/no/not applicable), age (numeric), sex (male/female), race (chinese/malay/indian/others), history of diabetes (yes/no), history of hypertension (yes/no), smoking status (never/former/current), history of AMI/CABG/PTCA (yes/no), BMI (numeric), Killip class on admission (1/2/3/4), CPR in ambulance/ED (yes/no), random blood glucose within 72 h from onset (numeric), creatinine on admission (numeric), haemoglobin on admission (numeric), elevated first troponin within 72 h from MI onset (yes/no), left ventricular ejection fraction <50% during hospitalization (yes/no).