Table 2.
All STEMI + NSTEMI patients | All STEMI + NSTEMI patients discharged alive | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Death during hospitalization | Death within 30 days from MI onset | Death within 1 year from MI onset | Rehospitalization for HF within 1 year from MI discharge | Rehospitalization for MI within 1 year from MI discharge | ||||||
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Unadjusted | ||||||||||
LDL-C in mmol/l | 0.77 (0.74–0.80) | <0.001 | 0.65 (0.62–0.68) | <0.001 | 0.68 (0.66–0.70) | <0.001 | 0.97 (0.90–1.04) | 0.411 | 0.95 (0.89–1.03) | 0.220 |
Ordinal categories | ||||||||||
<1.8 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
1.8–2.5 | 0.68 (0.60–0.78) | <0.001 | 0.52 (0.46–0.58) | <0.001 | 0.58 (0.53–0.62) | <0.001 | 0.90 (0.68–1.19) | 0.451 | 1.05 (0.76–1.44) | 0.783 |
2.6–3.3 | 0.56 (0.49–0.65) | <0.001 | 0.37 (0.32–0.42) | <0.001 | 0.40 (0.36–0.44) | <0.001 | 0.95 (0.72–1.25) | 0.719 | 1.04 (0.76–1.42) | 0.821 |
3.4–4.0 | 0.45 (0.38–0.53) | <0.001 | 0.26 (0.22–0.30) | <0.001 | 0.29 (0.26–0.32) | <0.001 | 0.76 (0.56–1.03) | 0.078 | 0.86 (0.61–1.22) | 0.402 |
4.1–4.8 | 0.47 (0.38–0.58) | <0.001 | 0.25 (0.21–0.31) | <0.001 | 0.26 (0.23–0.30) | <0.001 | 0.77 (0.55–1.08) | 0.130 | 0.89 (0.61–1.30) | 0.553 |
≥4.9 | 0.37 (0.29–0.48) | <0.001 | 0.22 (0.15–0.33) | <0.001 | 0.32 (0.28–0.37) | <0.001 | 0.95 (0.66–1.36) | 0.775 | 0.88 (0.57–1.34) | 0.543 |
Adjusted* | ||||||||||
LDL in mmol/l | 0.81 (0.76–0.87) | <0.001 | 0.79 (0.74–0.85) | <0.001 | 0.88 (0.84–0.91) | <0.001 | 1.01 (0.93–1.10) | 0.795 | 0.98 (0.88–1.08) | 0.640 |
Ordinal categories | ||||||||||
<1.8 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
1.8–2.5 | 0.72 (0.60–0.86) | <0.001 | 0.62 (0.52–0.73) | <0.001 | 0.77 (0.68–0.86) | <0.001 | 0.83 (0.59–1.16) | 0.281 | 1.14 (0.76–1.70) | 0.519 |
2.6–3.3 | 0.62 (0.50–0.76) | <0.001 | 0.54 (0.44–0.66) | <0.001 | 0.66 (0.58–0.76) | <0.001 | 0.97 (0.69–1.36) | 0.854 | 1.32 (0.87–2.01) | 0.190 |
3.4–4.0 | 0.56 (0.43–0.72) | <0.001 | 0.46 (0.36–0.59) | <0.001 | 0.63 (0.53–0.73) | <0.001 | 0.95 (0.65–1.40) | 0.801 | 1.01 (0.63–1.61) | 0.968 |
4.1–4.8 | 0.60 (0.43–0.82) | 0.002 | 0.53 (0.40–0.70) | <0.001 | 0.66 (0.55–0.80) | <0.001 | 0.82 (0.53–1.27) | 0.381 | 1.03 (0.62–1.73) | 0.899 |
≥4.9 | 0.48 (0.34–0.70) | <0.001 | 0.45 (0.32–0.63) | <0.001 | 0.68 (0.55–0.85) | <0.001 | 1.12 (0.71–1.76) | 0.638 | 1.03 (0.57–1.84) | 0.930 |
*Adjusted for: oral medication for hyperlipidemia (yes/no/not applicable), age (numeric), sex (male/female), race (chinese/malay/indian/others), history of diabetes (yes/no), history of hypertension (yes/no), smoking status (never/former/current), history of AMI/CABG/PTCA (yes/no), BMI (numeric), Killip class on admission (1/2/3/4), CPR in ambulance/ED (yes/no), random blood glucose within 72 h from onset (numeric), creatinine on admission (numeric), haemoglobin on admission (numeric), elevated first troponin within 72 h from MI onset (yes/no), left ventricular ejection fraction <50% during hospitalization (yes/no).