Table 3.
Unadjusted and adjusted analysis examining the correlations between high density lipoprotein cholesterol levels and the primary and secondary outcomes in ST elevation myocardial infarction patients who underwent percutaneous coronary intervention.
| All STEMI patients | All STEMI patients discharged alive | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Death during hospitalization | Death within 30 days from MI onset | Death within 1 year from MI onset | Rehospitalization for HF within 1 year from MI discharge | Rehospitalization for MI within 1 year from MI discharge | ||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Unadjusted | ||||||||||
| HDL-C in mmol/l | 1.17 (0.89–1.53) | 0.264 | 1.13 (0.87–1.47) | 0.356 | 1.24 (1.03–1.50) | 0.020 | 1.09 (0.80–1.48) | 0.576 | 1.09 (0.75–1.58) | 0.638 |
| Ordinal categories | ||||||||||
| >=1.6 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
| 1.0–1.5 | 0.46 (0.33–0.64) | <0.001 | 0.41 (0.30–0.58) | <0.001 | 0.40 (0.31–0.52) | <0.001 | 0.69 (0.44–1.09) | 0.110 | 0.83 (0.46–1.51) | 0.543 |
| <1.0 | 0.55 (0.39–0.76) | <0.001 | 0.52 (0.37–0.72) | <0.001 | 0.46 (0.36–0.60) | <0.001 | 0.67 (0.43–1.06) | 0.085 | 0.79 (0.43–1.43) | 0.430 |
| Adjusted* | ||||||||||
| HDL-C in mmol/l | 1.22 (0.86–1.73) | 0.274 | 0.94 (0.62–1.42) | 0.760 | 1.03 (0.76–1.38) | 0.865 | 0.87 (0.56–1.37) | 0.552 | 1.12 (0.73–1.70) | 0.614 |
| Ordinal categories | ||||||||||
| >=1.6 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
| 1.0–1.5 | 0.55 (0.34–0.87) | 0.011 | 0.53 (0.34–0.84) | 0.007 | 0.56 (0.39–0.79) | 0.001 | 0.79 (0.42–1.47) | 0.449 | 1.34 (0.54–3.30) | 0.530 |
| <1.0 | 0.64 (0.40–1.04) | 0.072 | 0.77 (0.48–1.24) | 0.285 | 0.74 (0.52–1.06) | 0.103 | 0.94 (0.50–1.78) | 0.856 | 1.18 (0.47–2.96) | 0.727 |
*Adjusted for: oral medication for hyperlipidemia (yes/no/not applicable), age (numeric), sex (male/female), race (chinese/malay/indian/others), history of diabetes (yes/no), history of hypertension (yes/no), smoking status (never/former/current), history of AMI/CABG/PTCA (yes/no), BMI (numeric), Killip class on admission (1/2/3/4), CPR in ambulance/ED (yes/no), random blood glucose within 72 h from onset (numeric), creatinine on admission (numeric), haemoglobin on admission (numeric), elevated first troponin within 72 h from MI onset (yes/no), left ventricular ejection fraction <50% during hospitalization (yes/no), anterior MI (yes/no), symptom-to-balloon time (numeric).