Table 3.

Summary of CpG sites from cannabis-only and cannabis with tobacco users vs. non-users.

	Cannabis-only		Tobacco + Cannabis		Both
Differentially methylated loci (FWER = 0.05)	0		6
Differentially methylated loci (P < 0.001)
Total	521		533
Hypermethylated	420	80.6%	403	75.6%	2
Hypomethylated	101	19.4%	130	24.4%	1
Hyper (cannabis) Hypo (cannabis + tobacco)					1
Location
Intron	216	41.5%	264	49.5%
Exon	97	18.6%	65	12.2%
Exon Boundary	0		0
Promoter	89	17.1%	60	11.3%
3ʹ UTR	3	0.6%	1	0.2%
5ʹ UTR	0		0
3ʹ (downstream)	62	11.9%	76	14.3%
5ʹ (upstream)	54	10.4%	67	12.6%

Counts of significant sites at P = 0.001 and at a Benjamini and Hochberg adjusted P < 0.05. ‘Both’ indicates the number of CpG sites of each type that are present and shared across both analyses.

FWER family-wise error rate.