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. 2020 Apr 22;11:1931. doi: 10.1038/s41467-020-15521-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d Volcano plots of log₂-transformed ratios of phosphosite abundances between a MM.1S treated with 18 nM Cfz, b 10 nM Cfz, or d 10 μM melphalan compared to DMSO and c AMO-1 with 15 nM Cfz compared to DMSO. Significant upregulated sites are in red, while downregulated are in blue (>2-fold change, p < 0.05). SRSF-related sites are in orange. Circle size corresponds to summed SILAC intensities. e Top-ranked GO terms for genes with significantly upregulated phosphosites in MM.1S cells treated with 18 nM Cfz. f Top ranked KSEA-activated kinases (with at least 5 substrates) for MM.1S treated with 18 nM Cfz (top panel) and 10 μM melphalan (bottom panel).