Table 2:

Human DUB-E3 complexes operating on shared substrates

DUB	E3	Regulatory function of complex	Reference
DUB-E3 interactions that mediate ubiquitin switches or rheostats on a shared substrate
UCHL1	MDM2	UCHL1 antagonizes MDM2-mediated ubiquitylation of p53	[78]
UCHL1	TRAF6	UCHL1 antagonizes TRAF6-mediated ubiquitylation of TRAF3	[79]
USP7	TRIM27	USP7 interacts with MAGE-L2-TRIM27 to regulate WASH ubiquitylation and actin polymerization on endosomes	[25]
USP9X	WWP1	USP9X interacts with WWP1 to regulate DVL2 ubiquitylation and WNT signaling	[32]
USP10	RNF168	USP10 interacts with RNF168 to regulate TOP2α ubiquitylation and chromatin association	[80]
USP12	ITCH	USP12 interacts with ITCH to regulate Notch trafficking and degradation	[81, 82]
USP13	AMFR	USP13 interacts with gp78 to stabilize UBL4A and promote ERAD	[45]
USP15	βTrCP	USP15 interacts with βTrCP to regulate the stability of β-catenin	[29]
USP20	TRAF6	USP20 interacts with TRAF6 to regulate the ubiquitylation of β-arrestin2	[83] [58]
USP28	FBXW7	USP28 interacts with FBXW7 in nucleus to regulate MYC degradation	[84]
USP28	RCHY1	USP28 interacts with PIRH2 to regulate CHK2 degradation in the DNA damage checkpoint	[85]
USP36	FBXW7	USP36 interacts with FBXW7 in nucleoli to regulate c-MYC degradation	[86]
Polyubiquitin chain editing by DUB-E3 complexes
A20	A20	A20 performs a polyubiquitin chain editing event on RIP, replacing K63-linked polymers with K48-linked polymers, targeting RIP for degradation	[49]
CYLD	ITCH	An ITCH-CYLD complex performs a polyubiquitin chain editing event on TAK1, replacing K63-linked polymers with K48-linked polymers, targeting TAK1 for degradation	[53]