Table 2.
Arginine and lysine methylated proteins implicated in Neurodegeneration
| Protein | Amino acid residue | PRMT/PKMT | Reference |
|---|---|---|---|
| Arginine methylation | |||
| FUS/TLS | Unknown | PRMT1 | (Yamaguchi and Kitajo 2012) |
| C/EBPα | R35, R156, R165 | PRMT1 | (Liu et al. 2019) |
| FOXO1 | R248, R150 | PRMT1 | (Yamagata et al. 2008) |
| eIF2α | R52, R53, R54, R56 | PRMT7 | (Haghandish et al. 2019) |
| PTEN | R159 | PRMT6 | (Feng et al. 2019) |
| Lysine methylation | |||
| Tau | K163, K174, K180, K254, K267, K290 | Unknown | (Thomas et al. 2012) |
| Tau | K24, K44, K67, K190, K259, K267, K290, K311, K317, K353, K385 | Unknown | (Thomas et al. 2012) |
| ERα | K302 | SET7/9 | (Subramanian et al. 2008) |
| ERα | K266 | SMYD2 | (Jiang et al. 2014) |
| ERα | K235 | G9a/GLP | (Zhang et al. 2016) |
| HSPA1A (HSP72) | K561 | SETD1A | (Cho et al. 2012) |
| HSPA1, HSPA5, HSPA8 | K561 | METTL21A | (Cho et al. 2012) |
| ANT | K52 | FAM173A (mitochondrial) | (Malecki et al. 2019) |
| AKT | K140K142, K64 | SETDB1 | (Guo et al. 2019) |
| AKT | K64 | SETDB1 | (Wang et al. 2019) |