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. 2020 Apr 22;10:48. doi: 10.1186/s13613-020-00666-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Deterministic simulations of meropenem. a 1 g quid 8 h (30 min); b 2 g loading dose (30 min) followed by 1 g prolonged infusion (over 4 h) quid 8 h; c 2 g quid 8 h (30 min); d 2 g loading dose (30 min) followed by continuous infusion of 3 g/day. Solid lines: typical patient without liver failure; dashed line: typical acute-on-chronic liver failure patient; dotted horizontal line depict typical target concentrations as 4x European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values (ECOFF) for Pseudomonas spp. (4× ECOFF 2.0 mg/L = 8 mg/L)